RESCENT TRENDS OF CANDIDA INFECTION AND THERE SUSCEPTIBILITY TEST

Priya Shukla; Brij Nandan Singh; Mo. Gufran Khan

Volume : VI, Issue : VIII, August - 2016

RESCENT TRENDS OF CANDIDA INFECTION AND THERE SUSCEPTIBILITY TEST

Priya Shukla, Brij Nandan Singh, Mo. Gufran Khan

Abstract :

Introduction–With the increase in the number of immunocompromised individuals, there has been a consequent rise in the number of opportunistic infections and Candida spp have especially emerged as important pathogen in the group of patients. Further the rise in antifungal resistance is an important concern. Methodology– Duration of the study was from 2011–2015. Candida species were isolated from various clinical specimens and were subjected to speciation and antifungal susceptibility testing by the VITEK–2 System (Biomerieux, france). The antifungal agents tested were Voriconazole, Fluconazole, Itraconazole, Capsofungin, Amphotericin–B and Flucytosine. Results– A total of 270 Candida spp isolated from various clinical specimens were included in the study. Candida spp. were mainly isolated from urine 107(39%) followed by sputum 51(18%), Endotracheal aspirates 28(10%),Blood culture 26(9%) and Centre line tip 22(8%) etc. The most common spp. was Candida albicans (38%), the non–albicans Candida species form the remaining 61% of the total isolates, thus stressing their emergence as major fungal pathogens amongst them most common isolate were Candida tropicalis (30%) susceptibility pattern showed that Candida albicans were highly sensitive to Amphotericin– B (78%) followed by Fluconazole (77%) and flucytosine (77%), Itraconazole (68%) and Voriconazole (68%) Candida tropicalis were also highly sensitive to Amphotericin–B (87%) followed by Fluconazole(80%) and Flucytosine (91%), Itraconazole(63%) and Voriconazole(83%). Conclusion– Correct and rapid Speciation of Candida spp.is important because of variation in antifungal susceptibility of various species to different antifungals and also due to limited therapeutic option because of emergence of resistance to antifungal agents.