Volume : IX, Issue : II, February - 2019

RESEARCH ON CROSS SECTIONAL OBSERVATIONAL STUDY OF ENDOCRINAL DYSFUNCTION IN THALASSEMIA PATIENTS

Dr. Gaurav Gupta

Abstract :

INTRODUCTION ;Thalassemia is most common heterogeneous group of single gene disorders, AIM ;Primary objectives;To study the endocrinal abnormalities in patients of thalassemia major.,To find out correlation between age, sexand serum ferritin levels with endocrinal abnormalities in thalassemia patients.,Secondary Objectives To study growth and development in thalassemia major patients. MATERIALS AND METHODS This study was conducted in the Thalassemia Unit of the Department of Pediatrics, Deen Dayal Upadhyay Hospital, New Delhi, Cross sectional observational study (descriptive). It was a hospital based study.,STUDY SITE: Day care thalassemia unit of Deen Dayal Upadhyay hospital, New Delhi. In Thalassemia unit patients are being admitted for regular blood transfusion & investigated routinely.,STUDY DURATION: 1st October 2013 to 30thJune 2014 (9 months) SAMPLE SIZE:Sample size was calculated using the formula for descriptive study (Z²×p×q)/d². When the estimated prevalence of endocrinal disorder in Thalassemia major patients (p) = 75%, with the precision error of estimation (d) = 0.12 (or 12%), and α=0.05, β=0.02,a sample size of 50 cases is needed. DATA COLLECTION: 50 thalassemia patients more than 8 years of age both males & females who were on transfusion therapy attending outdoor or being admitted in Day care Thalassemia unitof Deen Dayal Upadhyay hospital were assesed by history and physical examination(as per proforma) and laboratory investigation taking care of inclusion & exclusion criteria. STATISTICAL ANALYSIS ;Descriptive statistics will be analyzed e CONCLUSION ;The present study was done to find out various endocrinal abnormalities in patients of thalassemia major and to find out correlation between age, sex and serum ferritin level with these endocrinal abnormalities. A total 50 cases of thalassemia major both male and female on regular transfusion were studied. In our study, endocrinal abnormalities like short stature, hypothyroidism , impaired glucose tolerance, delayed puberty & hypogonadism were found to be more frequently associated with patients of thalassemia major although not statistically significant. Osteopenia & Osteoporosis were found to be significantly associated with these patients especially in the higher age groups. Though endocrinopathies were found more in cases having high serum ferritin level (≥2000ng/dl) and higher age groups but correlation between age, sex and serum ferritin levels with endocrinal abnormalities was statistically not significant.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

RESEARCH ON CROSS SECTIONAL OBSERVATIONAL STUDY OF ENDOCRINAL DYSFUNCTION IN THALASSEMIA PATIENTS, Dr. Gaurav Gupta INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-2 | February-2019

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