Volume : VIII, Issue : III, March - 2018

RESPONSE EVALUATION IN HIV INFECTED CARCINOMA CERVIX PATIENTS

Dr. B. Padmavathi

Abstract :

 Back Ground: Carcinoma cervix is the most common gynecological cancer. It is second most common cancer in women. Invasive cervical carcinoma appears at the age of 44 and 52 years. It was observed that HIV patients with cervical cancer presented a decade earlier than un HIV cancer cervix patients.  Primary treatment is guided by International Federation of Gynaecology and Obstetrics (FIGO) stage. Stage IA, Primarily treated with surgery Radical Hysterctomy, Stage IA2 to IIA with surgery (or) radiation; Stage II B to IV B is treated with definite radiation (External beam radiotherapy achy therapy).

Aims:     This study is carried out to asses.

–       The response to radiotherapy in HIV seropositve  cancer cervix.

–       To compare  the responses to radiotherapy in HIV positive and no HIV cancer cervix patients.

–       Addition of concurrent chemotherapy to radiation in medical fit HIV patients can replicate the same beneficiary effects as non–HIV cancer cervix counter parts.

Methods: Total of 52 HIV positive (HIV was screened with ELISA) and 52 non HIV cases cervix were selected depending upon the histopathological report. All patients were given only RT and concurrent chemo–radiation.

Results: Stage wise distribution of cancer cervix  in HIV and non HIV patient was compared in either groups Stage III B (35.46% in HIV and 40.38% in non HIV) followed by Stage–IIB (34.61% in both HIV and non HIV groups) . Stage wise response to only RT and CONCURRENT CHEMORADITION in HIV and non HIV cancer cervix patients. The comparative analysis of RTVS CONCURRENT CHEMORADITION in HIV positive group has shown that stage IB to II A and III A all the patients  have complete response to only radiotherapy. All patients received only radiotherapy with minimal side effects like diarrhea and vomiting in concurrent chemo radiotherapy these side effects increased.

Conclusion: This study is four arm study conducted in basically HIV and non HIV cancer cervix patients receiving only RT and CC RT. Responses assessed with only RT and CONCURRENT CHEMORADITION in HIV and non HIV groups shows additional benefit with addition of chemotherapy

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.B.PADMAVATHI, RESPONSE EVALUATION IN HIV INFECTED CARCINOMA CERVIX PATIENTS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018

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