Volume : VIII, Issue : XII, December - 2018

Retrospective, observational, non-interventional analysis of Non-glycemic parameters with SGLT2I on Type 2 Diabetes Mellitus patients stable on OADs

Dr Sayak Roy

Abstract :

 Background: Sodium glucose co–transporter 2 inhibitors (SGLT2I) have been shown to have extra–glycemic beneficial effects for type 2 diabetic patients.

Objective: The objective of the study was to see the degree of changes of body parameters with degree change in HbA1c over 12 weeks and also find out the drug causing maximum changes in parameters after 12 weeks. This is a retrospective, observational, and single arm study. Thirty three T2DM patients matching the inclusion criteria and using SGLT2I (dapagliflozin, empagliflozin, and canagliflozin) were included for the study. Both glycemic parameters (Changes in HbA1c) and non–glycemic parameters (changes in BMI, total subcutaneous fat, total visceral fat, skeletal muscle of trunk, and waist circumference) were measured in the cases at baseline and after 12 weeks. Data was analyzed by SPSS version 21. P value < 0.05 was considered statistically significant.

Results: Out of the 33 patients, 17 (51.50%) were male and 16 (48.5%) were female.  There was a significant reduction in the overall mean levels of HbA1c% (p=0.014), Visceral Fat (p=0.0027), and Waist Circumference (p=0.012) after 12 weeks. Multiple regression analysis revealed that change in HbA1c was influenced by baseline BMI, visceral fat, skeletal muscle trunk, HbA1c but was not influenced by changes in other parameters and duration of diabetes. 

Conclusion: Different SGLT2I affect the non glycemic parameters like visceral fat and waist circumference change in T2DM patients independent of changes in HbA1c. Also, the three classes of SGLT2I used in the study had similar effects on the changes in glycemic as well as non glycemic parameters.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Retrospective, observational, non–interventional analysis of Non–glycemic parameters with SGLT2I on Type 2 Diabetes Mellitus patients stable on OADs , Dr Sayak Roy , INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-12 | December-2018


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