Volume : V, Issue : I, January - 2015

Retrospective Study of Serum LDH in Megaloblastic Anemia

Dr. B. P. Gore, Dr. Gajanan Kurundkar, Dr. Shreepad Bhat

Abstract :

Megaloblastic anemia is characterised by decreased hemoglobin level with elevated Mean Corpuscular Volume (MCV)1,2. Deficiency of vitamins –B12 and/ or Folic acid leads to impaired DNA synthesis leading to ineffective erythropoiesis and intramedullary haemolysis in patients of megaloblastic anemia. This leads to increased unconjugated bilirubin, serum LDH (Lactate Dehydrogenase) and some degree of cytopenia.2,3,4 Aims & Objectives: To study level of serum LDH in cases of megaloblastic anemia. Material and methods: This is a retrospective observational study. The study was conducted on patients admitted in Smt. Kashibai Navale Medical College & General hospital, Pune during the period of 1 July 2013 to 10 December 2014. The medical records of 340 patients of anemia were reviewed and 42 cases of Megaloblastic anemia were selected for study. Patients diagnosed as megaloblastic anemia with Hb ≤ 9 gm% & MCV ≥ 100 fl whose serum LDH level was measured were selected for the study. This study was aimed to assess the role of serum LDH in diagnosis of megaloblastic anemia. Conclusion: In this study, serum LDH level was significantly elevated in patients of megaloblastic anemia. Thus serum LDH level may have an important role in diagnosis of megaloblastic anemia.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

DR. B. P. GORE,DR. GAJANAN KURUNDKAR,DR. SHREEPAD BHAT Retrospective Study of Serum Ldh in Megaloblastic Anemia Indian Journal of Applied Research, Vol.5, Issue : 1 January 2015

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