Volume : IV, Issue : V, May - 2014

Risk of Developing Specific Aids–Defining Illnesses and Opportunistic Infections in Romanian Coinfected Patients with HIV and Hepatitis B Virus

Gabriela Juganariu, Egidia Miftode

Abstract :

Objectives: To assess the influence of HIV/HBV coinfection on the risk of opportunistic infections and AIDS– defining illnesses in HIV–infected patients in Northeastern Romania. Material and Methods: Retrospective study included 466 patients with HIV infection assessed at the Iasi HIV–AIDS Regional Center during 2000–2013 stratified into two groups according to the presence of HBV coinfection. Results: The prevalence of HIV/HBV coinfection was 19.9%. Coinfection was more frequent in the age group 20–29 years (86.5%). HIV infection was predominantly transmitted through parenteral routes (58.5% vs. 61.5%). In the coinfected group, lower CD4 counts (246.20 vs 296.86 cel/mm3) and higher mean HIV RNA levels (142,906 copies/ml) were found. A CD4 count ?200/ml and HIV RNA > 100,000 copies/ml were strong predictors for most opportunistic infections. Conclusions: HIV –HBV coinfected patients in our cohort had a  3.87 times higher risk of developing opportunistic infections and AIDS–defining illnesses. Keywords: coinfection HIV–HBV, opportunistic infections  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Gabriela Juganariu, Egidia Miftode Risk of Developing Specific Aids-Defining Illnesses and Opportunistic Infections in Romanian Coinfected Patients with HIV and Hepatitis B Virus Indian Journal of Applied Research, Volume.4, Issue.5, May-2014

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