ROCURONIUM VERSUS SUCCINYL CHOLINE FOR RAPID SEQUENCE INDUCTION AND INTUBATION

Dr. B S T Sai; Dr. B Swathi; Dr. Kalapala Abhilash; Dr. N. Partha Sarathy

Volume : VII, Issue : VI, June - 2017

ROCURONIUM VERSUS SUCCINYL CHOLINE FOR RAPID SEQUENCE INDUCTION AND INTUBATION

Dr. B S T Sai, Dr. B Swathi, Dr. Kalapala Abhilash, Dr. N. Partha Sarathy

Abstract :

Background: Maintenance of a patent airway is a basic and essential component of general anaesthesia through endotracheal intubation. Muscle relaxants are useful in providing adequate relaxation to enable laryngoscopy and intubation. Succinylcholine and Rocuronium are used. Objectives: 1) To evaluate whether reducing the intubating dose of Rocuronium shortens its duration of action at the same time providing clinically acceptable intubating conditions. 2) To compare effectiveness of Rocuronium and Succinylcholine. Methodology: This is a hospital based experimental study involving a total of 100 patients ASRAMS, ELURU. Patients of either gender aged between 18 to 65 years who were willing to volunteer for the study and who have given written and informed consent are included. Patients were randomly allocated to one of 5 groups using a computer–generated randomization table. Statistical analysis of the data obtained was done using SPSS version 16 trail. Results: The overall intubating conditions in the 5 groups, using the Pearson Chi square test, a significant difference was noted in intubating conditions in the different groups with a P value < 0.0001.The onset of neuromuscular blockade was fastest in the Succinylcholine group, followed by the Rocuronium 0.6 group and Rocuronium 0.3 group, using the Mann–Whitney test with P value < 0.0001.The longest duration of neuromuscular blockade was in Rocuronium 0.6 group with P < 0.0001. Conclusion: Rocuronium in a dose of 0.3 mg/kg does not give clinically acceptable intubating conditions at 60 or 90 seconds. Rocuronium in a dose of 0.6 mg/kg gives clinically acceptable intubating conditions at 60 or 90 seconds that are comparable to intubation at 60 seconds following succinylcholine 1 mg/kg. Reducing the dose of rocuronium to 0.3 mg/kg shortens the duration of action but at the expense of providing clinically unacceptable intubating conditions.