Role of Adiponectin, Interleukin-6 and somatic DNA damages for predicting cardiovascular diseases among subjects with Prehypertension

Anaswara AA; Sharmila K; Aishwaria J; Viji Krishnan; Dinesh Roy D

Volume : IX, Issue : XII, December - 2019

Role of Adiponectin, Interleukin-6 and somatic DNA damages for predicting cardiovascular diseases among subjects with Prehypertension

Anaswara Aa, Sharmila K, Aishwaria J, Viji Krishnan, Dinesh Roy D

Abstract :

Prehypertension is one of the important potential candidates and independent predictor for both cardiovascular and cereovascular diseases. Newer biomarkers for the early diagnosis and prediction for cardiometabolic syndrome and CVD events among prehypertension is essential. The aim of the present study is to assess the role of Adiponectin and Interleukin–6 (IL–6) among prehypertensive subjects and to correlate with the various risk factor associate with Cardiometabolic Syndrome in prehypertensive subjects. A case–control study was conducted. The study group included 157 clinically diagnosed prehypertentsive subjects and 100 age and sex matched healthy control subjects. Adiponectin and Interleukin–6 (IL–6) had a significant role in association with somatic DNA damage in prehypertensive subjects and its earlier prediction of CMS. The increased mean CBMN frequency among the study subjects with 95% of confidence interval revealed its predictability for CMS. Adiponectin and interleukin–6 were also proved its strong predictability for CMS. Overall, this study recorded wider understanding of biochemical and molecular events in prehypertensive subjects which leads to high risk for CVD.