Role of Antioxidants in Protection Against Potassium  Bromate Induced Lipid Peroxidation in the Rat  Thyroid Gland

Dr. Shereen M. Samir; Dr. Abeer F. Mostafa

Volume : IV, Issue : II, February - 2014

Role of Antioxidants in Protection Against Potassium Bromate Induced Lipid Peroxidation in the Rat Thyroid Gland

Dr. Shereen M. Samir, Dr. Abeer F. Mostafa

Abstract :

Potassium omate (KBrO₃) has been classified as possible human carcinogen. Oxidative stress plays a major role in the carcinogenic action of KBrO₃. So, the aim was to prove the prooxidative effect of KBrO3 and to evaluate and compare the possible protective effect of melatonin and ascorbic acid against lipid peroxidation in the thyroids. Study was done on six groups of rats: (control group) treated with 0.9% NaCl: ethanol (v/v 10:1), or KBrO₃ in group II, or melatonin in group III, or ascorbic acid in group IV. Rats in groups V and VI were received either melatonin, or ascorbic acid combined with KBrO₃. The results prove lipid peroxidation in the rat thyroid, followed KBrO₃ injection. Treatment with melatonin or ascorbic acid did not affect the basal lipid peroxidation. However, the pre-treatments with either antioxidant ameliorate the lipoperoxidative changes and increase the expression of antioxidant enzymes in rat thyroid. In Conclusion, it is possible that these antioxidants may be of great value as protective agents against KBrO3-induced tumor induction in the thyroid. Melatonin is more powerful antioxidant than ascorbic acid.