Volume : X, Issue : II, February - 2020

ROLE OF Ki67 IN ORAL PREMALIGNANT AND MALIGNANT SQUAMOUS CELL LESION

Dr. Mahendra Singh, Dr. Monika Verma

Abstract :

Aims–To study Ki67 expression in oral premalignant lesion & its comparison with malignant lesion. Material and methods– The standard immunohistochemical method along with MIB–1 DO–7;DAKO antibodies was use to study the expression of Ki67 in paraffin embedded tissue specimens. Results– all sample study showed positive staining for ki67, only 9% case from oral squamous cell carcinoma(OSCC) group showed negative staining for ki67. The staining was confined to basal layer in most of the cases except OSCC in which it was seen in all layers. The intensity of staining was moderate to intense. The percentage of ki67 positive cells in malignant mucosa was 91%. The statistical analysis revealed that the expression of ki67 increases from dysplasia to malignancy. Conclusion– these results emphasize the potential use of ki67 antigen as marker of malignant transformation and carcinogenesis in oral premalignant lesions, conditions and OSCC, respectively; and in future they may serve as prognostic tools in the early detection of malignant transformation in oral premalignant lesions and conditions.

Keywords :

Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

ROLE OF KI67 IN ORAL PREMALIGNANT AND MALIGNANT SQUAMOUS CELL LESION, Dr. Mahendra Singh, Dr. Monika Verma INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-2 | February-2020

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