ROLE OF N–ACETYL CYSTEIN, METFORMIN AND VITAMIN D3 WITH CALCIUM ON METABOLIC PROFILE IN PCOS

Dr.Veena Gupta; Dr. Amita Yadav

Volume : VII, Issue : IX, September - 2017

ROLE OF N–ACETYL CYSTEIN, METFORMIN AND VITAMIN D3 WITH CALCIUM ON METABOLIC PROFILE IN PCOS

Dr. Veena Gupta, Dr. Amita Yadav

Abstract :

Objective – This study was aimed to evaluate the role of N–Acetyl cystein, metformin and vitamin D3 with calcium on the metabolic profile in PCOS .Material and Methods–The present study was conducted in the department of obstetrics and gynecology ,Motilal Nehru medical college, Allahabad over a period of 12 months. The study was carried out in 66 women of reproductive age group. The diagnosis of PCOS was made if the patients had two out of three Rotterdam criteria. RESULT– Reduction in fasting plasma glucose among all the three groups was statistically insignificant (p=0.1135) ). Post treatment greater reduction in fasting plasma glucose was seen in N–acetyl cysteine(p=0.0001) compared to Metformin and Vitamin D3 with Calcium ( p=0.0002 and p=0.0028 respectively) The difference in mean value of fasting plasma glucose/ fasting insulin ratio between Group 1 and Group 2 was insignificant. (p>0.05) and between Group 2 and Group 3 (p<0.05) as well as in Group 1 and Group 3 (p<0.01) was significant.

CONCLUSION– Highly significant changes ought by a 12 week course of treatment with NAC suggested that, longer treatment with N–acetyl cysteine may result in more desirable outcomes, such as more effective control of clinical symptoms of PCOS.