Volume : IX, Issue : IV, April - 2019

ROLE OF N TERMINAL PRO BRAIN NATRIURETIC PEPTIDE IN PREDICTING THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH CHRONIC STABLE ANGINA.

Dr S N Routray, Dr P K Nayak

Abstract :

BACKGROUND :– N terminal–pro Brain Natriuretic peptide (NT–pro BNP) a biomarker, has been extensively studied as a prognostic marker in acute clinical settings in acute coronary syndrome and heart failure. OBJECTIVES– The aim of the study is to evaluate correlation between a non invasive biomarker N terminal–pro Brain Natriuretic Peptide (NT pro BNP) and severity of coronary atherosclerosis confirmed by coronary angiogram in patients with chronic stable angina with preserved left ventricular systolic function. METHODS :– 61 patients with chronic stable angina having preserved ejection fraction were enrolled. Echocardiographic left ventricular ejection fraction was calculated either by QUINONES method or by SIMPSONS method. NT Pro–BNP was measured in all recruited patients within 12h of hospitalization using GLORIA method. All patients underwent diagnostic coronary angiography. GENSINI scoring system was used to calculate the coronary artery disease severity. The levels of NT pro–BNP were correlated with angiographic disease severity including GENSINI score. RESULTS :– NT–pro BNP levels were significantly higher in patients with coronary artery disease. Highest levels of NT pro BNP was 420pg/ml noted in patients with triple vessel disease with a mean value of 211.33±89.84.Finally inference was there is statistically significant difference between 0–2, 0–3 and 1–2, 1–3 vessel involvement but no significant difference between 0–1 and 2–3 vessels involvement in view of rise NT pro BNP (0=Minor CAD,1=SVD,2=DVD,3=TVD) . CONCLUSION :– Level of NT pro BNP may be useful to predict the presence of angiographically determined significant coronary artery disease in patients with chronic stable angina with preserved left ventricular systolic function. The NT pro BNP levels were positively correlated with number of coronary vessel involved. NT pro BNP has a good correlation with coronary artery disease severity calculated by GENSINI scores.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ROLE OF N TERMINAL PRO BRAIN NATRIURETIC PEPTIDE IN PREDICTING THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH CHRONIC STABLE ANGINA., DR S N ROUTRAY, DR P K NAYAK INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

Number of Downloads : 189

References :