ROLE OF SERUM INSULIN HORMONE LEVEL IN PREDICTION OF PREGNANCY OUTCOME IN WOMEN WITH EARLY PREGNANCY LOSS

Dr Sheela Maddeshiya; Dr Meena Dayal; Dr Urvashi Barman Singh; Dr Shakti Jain

Volume : X, Issue : IV, April - 2020

ROLE OF SERUM INSULIN HORMONE LEVEL IN PREDICTION OF PREGNANCY OUTCOME IN WOMEN WITH EARLY PREGNANCY LOSS

Dr Sheela Maddeshiya, Dr Meena Dayal, Dr Urvashi Barman Singh, Dr Shakti Jain

Abstract :

Introduction: Early pregnancy loss occurs in both natural and in–vitro fertilization mediated pregnancies. Clinical miscarriages occur in 8% of pregnancies. Most clinically apparent miscarriages occur during the first trimester& etiology is often unknown. Aim: To determine and compare the level of serum Insulin in cases of unexplained early pregnancy loss and previous normal pregnancies and to observe the association between level of serum Insulin and pregnancy outcome. Methodology :This case control study was carried out on total of 77 pregnant women in first trimester attending outpatient department and indoor cases in Swaroop Rani Nehru hospital and Kamla Nehru Memorial hospital, Prayagraj over a period of twelve months from September 2018 to August 2019.Patients were divided in two groups: Group I (n=52) included women with history of previous abortion and Group II (n=25) included women with history of no previous abortions. Serum level of Insulin hormone was measured using enzyme– linked immunosorbent assay (ELISA ) technique. Result: In this study serum Insulin hormone levels were higher in cases with history of previous early pregnancy loss compared to control (p<0.0001) and their levels were higher in cases who aborted during the study than the women who had successful continuation of pregnancy. Conclusion: Hyperinsulinemia was associated with early pregnancy loss. Estimation of the serum level of Insulin hormone could be used in cases of early pregnancy loss as a predictor of pregnancy continuation.