SAC mediated modulation of HepG2 cell survivability an in vitro study

Sujan Chatterjee; Debadrita Pal; Ankita Malakar; Udipta Chakraborti; Dipanwita Sengupta; Avik Sarkar; Soumosish Paul; Kaustav Dutta Chowdhury; Gobinda Chandra Sadhukhan

Volume : V, Issue : XII, December - 2015

SAC mediated modulation of HepG2 cell survivability an in vitro study

Sujan Chatterjee , Debadrita Pal, Ankita Malakar, Udipta Chakraborti, Dipanwita Sengupta, Avik Sarkar, Soumosish Paul, Kaustav Dutta Chowdhury, Gobinda Chandra Sadhukhan

Abstract :

Cancer is a group of diseases having a common characteristic of abnormal cell growth with a potential to invade other parts of the body. Available cancer therapeutics mostly includes chemotherapy, radiation, and/or surgery. Thinking of side effects during and after these treatments the therapy with herbal drugs is considered as a possible alternative to fight the cancer. In our study HepG2 cells, a suitable model for liver hepatocellular carcinoma, was treated with SAC, an organosulfur present in garlic. Data suggested effective suppression of HepG2 cell survivability by 48hr treatment of 10mM SAC. Further analysis recommended the important role of caspase3 mediated apoptosis in the SAC mediated curbing of hepatocarcinoma during in vitro study.