Volume : IX, Issue : VII, July - 2019

Salivary and serum biomarkers in oral lichen planus– a systematic review

Dr Lekshmy Jayan, Dr Ramya R, Dr Ramya M

Abstract :

Introduction: Lichen planus is an autoimmune T cell mediated mucocutaneous disorder, the etiology of which is still uncertain even after years of research. Numerous studies have been conducted using various markers in lichen planus in both serum and saliva, yet we don’t have a reliable marker for their diagnosis. In the past decade, researchers have shown to be more biased towards studies in salivary markers or studies to compare levels of known and established serum markers with that in saliva in an attempt to prove these non invasive alternative of saliva can also be a striking alternative in diagnosing many lesions. Objective: The aim of our study was to conduct a systematic review to evaluate and compare the serum and salivary biomarkers in lichen planus to see if serum or salivary markers are more reliable in its diagnosis. Materials and methods: Articles published till 2019 January were chosen for the study. Articles were chosen for the study in accordance with the inclusion and exclusion criteria and PRISMA checklist was followed for selection of the articles for this study. Results: Total of 159 articles were obtained after searching databases like PUBMED, EMBASE, LILACS and after screening the collected articles following the inclusion and exclusion criteria 14 articles were selected and analysed. Conclusion: It was inferred that the existing knowledge is not sufficient to come to conclusion on the efficiency of markers for oral lichen planus. Also, levels of INF– gamma, TNF– alpha and TNF receptor–2 were reduced following steroid therapy suggestive of their use in monitoring effectiveness of therapy. Future studies on markers correlating to the autoimmune nature of the lesion should be done for more reliable results.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

SALIVARY AND SERUM BIOMARKERS IN ORAL LICHEN PLANUS- A SYSTEMATIC REVIEW, Dr Lekshmy Jayan, Dr Ramya R, Dr Ramya M INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-7 | July-2019

Number of Downloads : 823

References :