Volume : IV, Issue : VI, June - 2014

Screening of Anti–hyperglycemic Activity of Kigelia africana on Alloxan–Induced Diabetic Rats

Bhanu Priya, Manoj Gahlot, Punam Joshi

Abstract :

The present study was carried out to evaluate the anti–hyperglycemic activity of methanol extract of Kigelia africana leaves in Alloxan–induced diabetic rats for its purported use in diabetes. Hyperglycemia was induced in rat by injection of Alloxan (120 mg/kg, i.p.). Treatment was done by methanolic leaves extract of Kigelia africana (KA–ME) at dose range of 100–400 mg/kg, p.o for 21 days. Control group received normal saline (0.9%) for 21 days. Glibenclamide (5 mg/kg, p.o) was used as a reference drug. Blood samples were collected from all the groups and analyzed for serum glucose and lipid levels such as total cholesterol (TC), triglyceride (TG), proteins (TP). KA–ME was also tested for oral glucose tolerance test (OGTT) in normal fasted rats. KA–ME (200 & 400 mg/kg, p.o) showed a significant (P<0.01) reduction of serum glucose TC, TG, and TP level in Alloxan–induced diabetic rats as compared with diabetic control. KA–ME (200 & 400 mg/kg, p.o) significantly (P<0.01) increased the glucose tolerance in OGTT. The results obtained from the present study revealed the potential anti–hyperglycemic activity of methanolic extract from the leaves of Kigelia africana.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Bhanu Priya, Manoj Gahlot, Punam Joshi Screening of Anti-hyperglycemic Activity of Kigelia africana on Alloxan-Induced Diabetic Rats Indian Journal of Applied Research, Vol.IV, Issue.VI June 2014

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