Volume : IV, Issue : IX, September - 2014

Screening of Antibacterial Activity of Marine Sponges Extract Against Clinically Significant MDR Pathogens.

Prashanthi, B . , Vidya, S. , Vigneshwari. , Selvasundhari, L. , Vinola Jenifer, S. , Jeyasudha, S. Babu, V, Govindasamy Thiruneelakandan

Abstract :

The large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture resulted in the selection of pathogenic bacteria resistant to multiple drugs. Most bioactive compounds from sponges include anti–inflammatory, antitumor, antiviral, anti–malarial, and antibiotic or antifouling, immunosuppressive or neurosupressive. Hence, our present investigation of marine sponges extracted and fraction was tested against MDR (Multi Drug Resistant) pathogens isolated from clinical samples. Ethanol extract of marine sponges was effective in controlling the pathogen. Ethanol extract of marine sponges was most effective against E.coli (16.3mm) observed in extract at 50 µg concentration followed by salmonella and P.aeuroginosa (16.0mm). Qualitative and quantitative analysis of the Ethanol extract of marine sponges revealed the presence of flavones, alkaloids, tannins and sponins. Thin layer chromatography and GC–MS, FT–IR analysis confirmed the presence of secondary metabolites.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Prashanthi, B ., Vidya, S., Vigneshwari., Selvasundhari, L., Vinola Jenifer, S., Jeyasudha, S. Babu, V, Govindasamy Thiruneelakandan Screening of Antibacterial Activity of Marine Sponges Extract Against Clinically Significant MDR Pathogens. Indian Journal of Applied Research, Vol.4, Issue.9 September 2014

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