SCREENING OF CYTOTOXICITY POTENTIAL OF 6–HALOARYL BENZIMIDAZOQUINAZOLINES IN HELA CELLS

C.Nisha shri; Ajithadas Aruna; T. Vetrichelvan

Volume : V, Issue : IX, September - 2015

SCREENING OF CYTOTOXICITY POTENTIAL OF 6–HALOARYL BENZIMIDAZOQUINAZOLINES IN HELA CELLS

C. Nisha Shri, Ajithadas Aruna, T. Vetrichelvan

Abstract :

Cervical cancer is the second most common cancer in women worldwide, and vaccines are currently available. The vaccines can be prophylactic, but not therapeutic. So, in this study attempts was taken to screen synthesized benzimidazo [1,2–c] quinazoline derivatives antitumor potential towards the cervical cancer cells. In vitro anticancer screening was done by MTT assay. Out of all the compounds synthesized 6–(2,6–dichlorophenyl)– benzimidazo[1,2–c] quinazoline revealed 98.2 % cellular inhibition and IC50 value of about 6.4 µM. The percentage of cell inhibition demonstrated by the compound was more, whereas the IC50 values were less when compared with that of the standard drug etoposide.