SECOND TRIMESTER BETA HCG ESTIMATION FOR PREDICTION OF HYPERTENSIVE DISORDER

Ashish K. Bhattacharjee; Bishnu Prasad Das; Farjana Habiba Ahmed

Volume : VIII, Issue : XII, December - 2018

SECOND TRIMESTER BETA HCG ESTIMATION FOR PREDICTION OF HYPERTENSIVE DISORDER

Ashish K. Bhattacharjee, Bishnu Prasad Das, Farjana Habiba Ahmed

Abstract :

Background: Gestational hypertension is the development of hypertension in a pregnant woman after 20 weeks of gestation. Women with high serum beta–HCG levels in early pregnancy are at higher risk of developing hypertensive disorder. Aim: The present study aims to find the relationship between serum Beta–HCG levels at mid trimester (13–20 weeks) and development of hypertensive disorder. Material and Methods: Serum beta–HCG estimation was done by CLIA method in 110 women between 13 to 20 weeks of gestation, selected randomly for this study from June 2017 to May 2018. Multiple of median (MOM) was calculated from the median of the diagnostic test, Diagnostic Products Corporation, U.S, Immulite 2000– HCG, for that weeks of pregnancy. Cases were followed till delivery for the development of hypertension and results analysed statistically with Chi–square test. Result: Out of 110 cases, 94 (85.5 %) were finally evaluated in which 84 cases (89.4%), had Beta– HCG levels, <2MOM, whereas 10 cases (10.6%), had values >2 MOM. Out of 84 cases with Beta–HCG levels < 2 MOM, only 2 cases (2.1%) developed hypertension. The remaining cases, 82 (87.42%), were normotensive and out of 10 cases with Beta–HCG values >2MOM, 8 cases (8.5%) developed hypertensive disorder, and only 2 cases (2.1%) were normotensive. The p value for this parameter when calculated for the development of pregnancy induced hypertension, came out to be <.001, which is highly significant. Conclusion: The study concluded that the serum beta HCG estimation at mid trimester (13–20 weeks) is a good predictor of development of hypertensive disorder.