Volume : IV, Issue : XII, December - 2014

Serum Calcium in Duchenne/Becker Muscular Dystrophy Patients of Gujarat Population

Sindhav, G. M, Rao, M. V.

Abstract :

The dystrophinopathies, DMD and the allelic BMD are the most common forms of muscular dystrophy in humans. Duchenne Muscular Dystrophy (DMD) is one of the most common inherited neuromuscular disease affecting only males. It is an X–linked recessive disorder caused by mutation in the dystrophin gene. The present study aimed to rule out the pathological role of serum calcium (Ca) level in D/BMD patients and their correlation with gene deletion and age. Out of total 80 suspected D/BMD patients, 58 (72.5%) patients were confirmed using M–PCR for evaluation of 26 exons. The serum Ca level showed a significant (p<0.05) decrease in DMD, as well as inverse correlation with advancing age in DMD only. In addition, study also revealed no correlation between Ca and deletion pattern of exon/s. The present observations thus conclude that Ca level with clinical diagnosis could be meaningful from the etiologic and therapeutic points of view.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Sindhav, G. M,Rao, M. V. Serum Calcium in Duchenne/Becker Muscular Dystrophy Patients of Gujarat Population Indian Journal of Applied Research, Vol.4, Issue : 12 December 2014

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