SERUM CREATINE KINASE AND MAGNESIUM AS PROGNOSTIC INDICATORS IN OP COMPOUND POISONING

Dr.SUDHAKAR P; Dr.BLESSY MANOHAR. V; Dr.NIKHITHA K.

Volume : VII, Issue : XII, December - 2017

SERUM CREATINE KINASE AND MAGNESIUM AS PROGNOSTIC INDICATORS IN OP COMPOUND POISONING

Dr. Sudhakar P, Dr. Blessy Manohar. V, Dr. Nikhitha K.

Abstract :

Agriculture constitutes the major component of Indian economy. Pesticides are wonderful human inventions used for the control of pests, weeds or plant diseases to improve the cultivation of agricultural products. It also had been used as chemical warfare weapons. Organophosphorus (OP), the commonest agent for poisoning in India due to its easy availability, acts by inhibiting acetylcholinesterase at muscarinic and nicotinic receptors.Erythrocyte cholinesterase (EchE) and plasma cholinesterase (PchE) are reduced in OP poisoning, but their estimation is costly and not regularly performed. There are emerging options for new cheaper biochemical markers in relation to OP poisoning. Serum level of creatine phosphokinase (CPK) is often found to be elevated and serum magnesium is often reduced in OP poisoning. This study was conducted to see if CPK and magnesium may be used as an alternative of cholinesterase levels in blood to assess the severity of OP poisoning. This was a prospective and observational study. Sixty patients of OP poisoning without any prior treatment, presenting within 12 hours, were selected and their clinical severity was categorized according to Peradeniya organophosphorus poisoning (POP) scale.Level of serum CPK, blood EchE and serum Mg were measured following admission, and total dose of atropine (mg) until the final clinical outcome (complete recovery or death) was calculated. Our study recommends serum CPK and Magnesium as alternative markers