Serum free and total Prostate Specific Antigen with Carcino Embryonic Antigen- level in breast carcinoma and benign breast disease :A comparative analysis

Suparna Datta; Swati Bhattacharyya

Volume : VIII, Issue : X, October - 2018

Serum free and total Prostate Specific Antigen with Carcino Embryonic Antigen- level in breast carcinoma and benign breast disease :A comparative analysis

Suparna Datta, Swati Bhattacharyya

Abstract :

Introduction:Breast cancer is the commonest cancer among women in urban India. The identification of blood biomarkers for early detection of east cancer is an important target of research. USG &Mammography, the current routine method for early detection, has a limited sensitivity for the detection of tumors in remote area & in patients with dense east tissue .Moreover,they are available in only tertiary care hospital in India, so it is not accessible for all patients. North East India is mostly hilly region ,so women with east disease can not reach those hospitals easily, but blood samples can be collected easily through local Health Care Delivery System.A panel of potential cancer biomarkers for east cancer was selected in order to study their combined predictive value for early detection of east cancer. Serum markers such as CEA, free and Total PSA were selected for the present study.

Objective:In the present Study ,an attempt was made to compare efficacy of free & total P.S.A as a tumour marker in east carcinoma in comparison with C.E.A .

Materials & methods: Institution based case control Study conducted in North Bengal Medical College & Hospital.

Study Population :– Female patients aged 20–70 yrs has been divided into groups 1. Diagnosed east carcinoma (by biopsy/FNAC), 2. Patients with benign east diseases (biopsy/FNAC) and 3.Healthy control ,attending North Bengal Medical College & hospital.

Sample Size:–90 individuals (30 in each group). ELISA performed for all three tumour markers by using standard kit.

Result:Serum CEA &tPSA markers are significant in differentiating between benign and carcinoma group. Serum CEA is the only significant marker in differentiating between healthy subjects and Carcinoma group.

Conclusion: Serum tPSA&fPSA values are markers of diseased east according to the present study. Serum CEA is the only relevant marker in differentiating normal and east carcinoma group