SERUM LEVELS OF C–REACTIVE PROTEIN, HEPCIDIN AND INTERLEUKIN–6 IN ACUTE CHOLECYSTITIS AND ITS CORRELATION WITH SEVERITY OF ATTACK AND RECOVERY TIME

Shaji Thomas; Gunjan Desai; Suhani Gupta; Monisha Choudhury; Shadan Ali; Sanjeev Kumar Tudu

Volume : VII, Issue : VII, July - 2017

SERUM LEVELS OF C–REACTIVE PROTEIN, HEPCIDIN AND INTERLEUKIN–6 IN ACUTE CHOLECYSTITIS AND ITS CORRELATION WITH SEVERITY OF ATTACK AND RECOVERY TIME

Shaji Thomas, Gunjan Desai, Suhani Gupta, Monisha Choudhury, Shadan Ali, Sanjeev Kumar Tudu

Abstract :

Background. Prognostic markers for acute cholecystitis are not yet established in literature.

Aim. To document levels of C–reactive protein, Hepcidin and Interleukin–6 in acute cholecystitis, and their correlation with disease severity and recovery time.

Methods. This prospective observational study was conducted in a tertiary care hospital in north India. 41 patients with acute cholecystitis were included. Blood samples were collected for evaluation of the three markers at the time of admission and levels were correlated with duration of complaints, severity of acute cholecystitis, and the time taken for recovery.

Observations. Levels are increased in patients with acute cholecystitis, and correlate with the total leukocyte counts at the time of admission, duration of pain before admission, disease severity, and time taken for recovery.

Conclusion. The marker levels will not aid in diagnoses of acute cholecystitis, assess severity, help predict the disease course and time required for recovery.