Volume : VII, Issue : VI, June - 2017

SIGNIFICANCE OF S.AMYLASE IN GASTROINTESTINAL PERFORATION

Dr Gyan Prakash Rastogi, Dr. S. C . Sharma, Dr. S. P. Sinha

Abstract :

 Background:The fact that a certain number of patients with perforation have significantly elevated serum and peritoneal fluid amylase is widely known. Elevated serum amylase is a frequent concomitant of perforated gastrointestinal perforation. A study was made of the clinical records of 100 patients with gastrointestinal perforation to determine if there might be significant correlation between increased serum amylase and site of perforation.This rise in serum amylase comes about in cases of perforated peptic ulcer as a result of peritoneal lymphatic absorption of fluid containing pancreatic enzyme which is spilled through the perforation.The factors of amount of fluid spill, duration of the perforation, size of perforation, site of perforation were also studied for possible relationship with elevated serum amylase. Other aspect of study was where to give incision as it takes more time because it is very difficult to decide exact site of perforation (gastroduodenal or intestinal) higher level were recorded in former not in later .   Material and Methods:A prospective study was done of all the patients admitted with diagnosis of gastrointestinal perforation and treated at TMU from 12 March 2014 to 10 June 2015.100 cases were studied with perforation presented in casualty in TMMC&RC. Blood and fluid was taken at the time of admission and were analyzed for amylase estimation by modified somgyi method. This includes 83 male and 17 female patients.Out of these 100 patients 62 patients were gastric                   perforation and 38 patients were intestinal perforation.   Results:Out of these 100 patients 62 patients belongs to gastroduodenal perforation and 38 patients belongs to enteric perforation.Approximately 93%  patients with gastroduodenal perforation having increased serum amylase levels, on the other hand approx. 13% patients with enteric perforation have increased serum amylase level. Result also shows the relation of size of perforation to serum amylase level. Conclusion: Study shows that the l serum amylase level depends on factors like site of perforation, size of perforation. Significant elevation of serum amylase level is found in patients with gastroduodenal perforation and with lareger size perforation.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Gyan Prakash Rastogi, Dr. S. C . Sharma, Dr. S. P. Sinha, SIGNIFICANCE OF S.AMYLASE IN GASTROINTESTINAL PERFORATION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017

Number of Downloads : 586

References :