Significance of Sequential Emergence of Serological Responses by Dengue Patients as Community Level Sero–Epidemiological Indicators of Disease Progression: A Study in Barmer, Rajasthan, India

Dr. Annette Angel; Dr. Bennet Angel; Dr. Vinod Joshi; Dr. Kiran Kucheria

Volume : IV, Issue : V, May - 2014

Significance of Sequential Emergence of Serological Responses by Dengue Patients as Community Level Sero–Epidemiological Indicators of Disease Progression: A Study in Barmer, Rajasthan, India

Dr. Annette Angel, Dr. Bennet Angel, Dr. Vinod Joshi, Dr. Kiran Kucheria

Abstract :

Dengue & Dengue Haemorrhagic Fever have emerged as major public health problem in India. A prolonged outeak of DF & DHF has been reported from Barmer, Rajasthan. Sequence in emergence of serological parameters, NS1 viral protein and IgM antibodies by the dengue patients is the focus in the present study. As outeak progressed the proportion of cases carrying NS1 antigen decreased and IgM antibodies increased from the month of August to December, 2013. The descending trend of NS1 protein and ascending trend of IgM antibodies coincided with reduction in disease load as only 31 cases were recorded till 15th December. We infer that extrinsic stock of virus is not infecting a new case in a serially progressing outeak but intrinsic virus (Man to man), which is only antigenically sufficient to induceIgM antibodies and insufficient to remain in any more existence as the NS1 antigen is circulating across the population.    