Significantly Enhanced MDA levels in Rheumatoid  arthritis and Osteoarthritis cases as a measure of  oxidative damage

Dr. Arshia Fatima; Dr. Mohd Ishaq

Volume : VII, Issue : III, March - 2017

Significantly Enhanced MDA levels in Rheumatoid arthritis and Osteoarthritis cases as a measure of oxidative damage

Dr. Arshia Fatima, Dr. Mohd Ishaq

Abstract :

The main objective of the study was to investigate the ongoing free radical induce damage in Rheumatoid arthritis and Osteoarthritis patients by measuring the Malondialdehyde (MDA) level with a view to gain insight into the pathogenesis of these disorders. A total of 131 RA patients and 47 OA patients were studied along with 95 healthy controls were included in the study. The Mean MDA level in RA and OA patients were 509.20 ± 16.31 nmol/dl and 514.18 ± 25.23 nmol/dl respectively. These levels were significantly higher than that in the control group 205.78±9.87 nmol/dl. The significance of increased lipid peroxidation as assessed by MDA level in these two clinical conditions has been discussed.