SLEEP DOSE OF THIOPENTONE SODIUM Vs ETOMIDATE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY

Dr. Ajaykumar Anandan; Dr. Botta Bhagya Vardhan

Volume : IX, Issue : XII, December - 2019

SLEEP DOSE OF THIOPENTONE SODIUM Vs ETOMIDATE FOR ATTENUATION OF STRESS RESPONSE DURING LARYNGOSCOPY

Dr. Ajaykumar Anandan, Dr. Botta Bhagya Vardhan

Abstract :

BACKGROUND: Stress response resulting from intubation, extubation and surgical stimulus can lead to some haemodynamic changes like elevated heart rate and blood pressure. This may be detrimental in high risk patients like those with cardiac disease. This study aims to compare the haemodynamic effects of etomidate and thiopental by measuring cardiac output and arterial tension values at the stress response during laryngoscopy of patients undergoing elective surgery. MATERIALS AND METHODS: This prospective study was conducted on 60 adult, ASA grade–1 and 2 patients, aged between 18–60 years of either sex, undergoing elective surgeries in general surgery, orthopedics, urology and gynaecological surgeries. The patients were randomly assigned into two groups of 30 each.Group – E: Etomidate Group – T: Thiopentone. The hemodynamic parameters namely pulse rate, systolic and diastolic blood pressure were recorded before induction, after induction, after intubation 1 min, 3 minutes and 5 minutes after intubation. The data was analyzed using unpaired “t” test. RESULTS: Both the group were statistically comparable with regard to the mean heart rate where it was statistically significant at the induction and post intubation (P < 0.05). Group E showed a Both the groups were statistically comparable with regard to the systolic blood pressure and it was statistically significant at post induction (P < 0.05) Group E showed a stable systolic blood pressures when compared to Group T during induction & post intubation. better stability when compared to Group T at these time frames. CONCLUSION: It’s concluded that, in this study, the etomidate is safer than thiopental in terms of providing haemodynamic stability to the patient during induction and post intubation.