Spectral studies and synthesis of 10–substituted  6a, 7–dihydro–6H–7–(4–hydroxyphenyl) –  6–(4–methoxyphenyl) –[1] benzopyrano[3, 4–c][1,5]&n

Ved Prakash Bairwa; Prerna Jain; B.S. sharma

Volume : IV, Issue : I, January - 2014

Spectral studies and synthesis of 10–substituted 6a, 7–dihydro–6H–7–(4–hydroxyphenyl) – 6–(4–methoxyphenyl) –[1] benzopyrano[3, 4–c][1,5]&n

Ved Prakash Bairwa, Prerna Jain, B. S. Sharma

Abstract :

Diltiazem and clentiazem having 1,5-benzothizepine nuclei shows various biological activities so we are going to synthesize new 1,5-benzothizepine derivatives. For the synthesis of substituted 1,5- benzothiazepines, equimolar proportion of 5-substituted-2-amino benzenethiols, the substituents being fluoro,Chloro, omo, methyl, methoxy, and ethoxy were reacted with 2-(4-anisyl)-3-(4 hydroxybenzylidine)chromanone in dry toluene containing trifluoroacetic acid in catalytic amount to give respective 10-substituted 6a, 7-dihydro-6H-7-(4-hydroxyphenyl)- 6-(4-methoxyphenyl)- [1] benzopyrano [3,4-c][1,5]- benzothiazepines. The products were conveniently obtained by refluxing for 3 hours in good yield. The structural investigations are based on the result of microanalytical data of elements and spectroscopic studies based on IR, H¹ NMR, and mass spectra.