Spectral studies, synthesisand antibacterial evaluation of 8–substituted–2,3–dihydro–4–(2,4–dihydroxyphenyl) –2–(4– methoxyphenyl)–1,5– benzothia

Ved Prakash Bairwa; B.S. sharma

Volume : V, Issue : IX, September - 2015

Spectral studies, synthesisand antibacterial evaluation of 8–substituted–2,3–dihydro–4–(2,4–dihydroxyphenyl) –2–(4– methoxyphenyl)–1,5– benzothia

Ved Prakash Bairwa, B. S. Sharma

Abstract :

1,5–benzothizepine moiety shows various biological activities, play a major role in the field of pharmaceutical chemistry, motivate to synthesize new series of 1,5–benzothizepine derivatives. For the synthesis of 8–substituted–2,3–dihydro–4–(2,4–dihydroxyphenyl)–2–(4–methoxyphenyl)–1,5–benzothiazepines,equimolar proportion of 1–(2,4–dihydroxyphenyl)–3–(4–methoxyphenyl)–2–propenone were reacted with 5–substituted–2–amino benzenethiols, the substituent’s being fluoro,Chloro, omo, methyl, methoxy, and ethoxy in dry ethanol saturated with dry HCl gas, refluxing for 6 hours obtained in good yield. The structural investigations are based on the result of micro analytical data of elements and spectroscopic studies based on IR, H1 NMR, and mass spectra.