Volume : VIII, Issue : III, March - 2018

STROMAL EXPRESSION OF CD10 IN BREAST LESIONS: AN INSTITUTIONAL STUDY

Dr. V. Manikanta, Dr. P. Babu. Ukkadala, Dr. T. Bharath

Abstract :

 

BACKGROUND: Breast carcinoma 2nd most common cancer in India. Incidence of east cancer in India is on raise and rapidly overtaking the position of cervical cancers in females. Immunochemistry is very important role in confirming the diagnosis. The main aim of this study to correlate immunohistochemistry and histopathological grades of east carcinoma using the modified Bloom–Richardson system and TNM staging and helps management of east lesions.

MATERIALS & METHODS: This was a descriptive, cross sectional study carried out for 2 years from November 2013 to August 2015. Total 50 lumpectomy and mastectomy specimens were  received to department of pathology Dr.PSIMS & RF, chinnaoutpalli, Vijayawada, A.P. After gross examination biopsies were sections were given and processed, H&E staining , histopathological diagnosis was made out.  Immunohistochemistry was done for CD10. This study was approved by the institutional ethical committee.

RESULTS:  Total 50 biopsies were analyzed and oadly categorized into non–neoplastic and neoplastic lesions. Most of the lesion commonly presented at 31–40 years of the age. All the lesions showing equal laterality. Benign lesions are more predominant than malignant. Fioadenoma is the most common benign lesions 18(56%) and infiltrating duct cell carcinoma was the most common malignant lesion 18 (88.9%). Immunohistochemistry with CD10 was done for all the east lesions shows consistently positive in myoepithelial cells of benign east lesions and weakly positive in stromal cells of Infiltrating duct cell carcinoma.

CONCLUSION: Immunohistochemistry (IHC) CD10 status provides prognostic, diagnostic and therapeutic information. Stromal CD10 expression had a high specificity for differentiating between benign lesions (fioadenomas and benign phyllodes tumours) and malignant (borderline and frankly malignant) phyllodes tumours.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.V.MANIKANTA, Dr.P.BABU.UKKADALA, Dr.T.BHARATH, STROMAL EXPRESSION OF CD10 IN BREAST LESIONS: AN INSTITUTIONAL STUDY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-3 | March-2018


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