Studies on management of canine mammary tumours with dendritic cell therapy

A. K. Vala; P. V. Parikh; J. K. Mahla; D. N. Kelawala; S. Natesan

Volume : VIII, Issue : IV, April - 2018

Studies on management of canine mammary tumours with dendritic cell therapy

A. K. Vala, P. V. Parikh, J. K. Mahla, D. N. Kelawala, S. Natesan

Abstract :

The present study was carried out with multiple objectives.Twelve cases of canine mammary tumours were detail examined in two groups (6 in each group).Radiography of thorax revealed absent of metastases in all the cases. Ultrasonography revealed size, irregularities of margins as well as echogenicity of mammary tumour masses with vasculature, helping to differentiate their nature and clinical significance. After one month of completion of Dendritic cells (DC) immunotherapy (Group 1), size of tumour mass was increasedor remained constant in five case and in one case it disappeared. In surgery followed by DC immunotherapy (Group 2) protocol every case recovered uneventfully and no recurrence was observed. Data of MTT assay and IFNG+ indicated that DC therapy potentiate CMI response in this group of animals. Based on result, Surgery followed by DC therapy group was proved good compared to immunotherapy group.From the above study it can be concluded that DC therapy was observed to be safe and well tolerated in all animals without any adverse effects or toxicity. Study provided novel insights on the benefit of DC based cellular immunotherapy for managing mammary tumours in canines. Further studies to improve the therapeutic efficacy of DC therapy in canines are required in the future.