Volume : X, Issue : VI, June - 2020

STUDIES ON WATER SOLUBLE HPMC GRADES FOR THE DEVELOPMENT OF PAROXETINE HYDROCHLORIDE ORAL FILM

Gangurde Ab, Teli Cc, Bairagi Va

Abstract :

The main objective of the present study was to compare the two grades of water soluble HPMC in the development of Paroxetine hydrochloride oral film. Taste mask complex of a paroxetine and mannitol was prepared using solvent evaporation method.The FTIR, DSC and TLC studies demonstrated no interaction in between Paroxetine hydrochloride, HPMC E5 and HPMC E50.The prepared films (F1–F8) were analysed for physical appearance, weight variation, thickness, tensile strength, folding endurance, drug content, disintegration and dissolution parameters. HPMC E5 showed better results for fast drug dissolution, and disintegration, while HPMC E50 showed better results for tensile strength and folding endurance at comparable and varying concentration range 4.5 %, 3.5%,2.5% ,1.5%.The better results of folding endurance, dissolution time, disintegration time and tensile strength suggested F2 formulation as better developed film which contains HPMC E5 (2.5%). The mouth dissolving film of Paroxetine hydrochloride was formulated with HPMC water–soluble E–5 gradedisintegrates within few seconds and releases drug rapidly to give its therapeutic effect. Low viscosity and better hydrophobicity with film forming ability of HPMC E5 confirm the suitability for preparation of oral mouth dissolving films for fast onset of action. The present study revealed that formulated paroxetine hydrochloride mouth dissolving film with E–5 grade has better oral film properties than HPMC E50

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

STUDIES ON WATER SOLUBLE HPMC GRADES FOR THE DEVELOPMENT OF PAROXETINE HYDROCHLORIDE ORAL FILM, Gangurde AB, Teli CC, Bairagi VA INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-6 | June-2020

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