STUDY OF ASSOCIATION BETWEEN VITAMIN D AND ENDOTHELIAL DYSFUNCTION IN HYPERTENSIVE PATIENTS: A HOSPITAL BASED STUDY

Adil Rahman; Kuldeep K. Gupta; Vijay K. Verma; Javed A. Siddiqui

Volume : IX, Issue : VIII, August - 2019

STUDY OF ASSOCIATION BETWEEN VITAMIN D AND ENDOTHELIAL DYSFUNCTION IN HYPERTENSIVE PATIENTS: A HOSPITAL BASED STUDY

Adil Rahman, Kuldeep K. Gupta, Vijay K. Verma, Javed A. Siddiqui

Abstract :

HIGHLIGHTS • Vitamin D deficiency can abate the endothelial function and support the pathogenesis of atherosclerosis. • Supplementation of vitamin D in deficient subject can markedly improve the endothelial function and cardiac health. Background: Endothelia cells produce endogenous vasodilator nitric oxide (NO) in response to local shear stress. Brachial artery flow – mediated vasodilatation (FMD), a measure of endothelium–dependent dilation. Vitamin D is known to affect function of endothelial cells through various regulatory mechanisms and its deficiency associated with decreased bioavailability of NO, leads to endothelial dysfunction associated with arterial stiffness and increase in cardiovascular disease risk. Aims and Objectives: To study the effect of vitamin D on arterial stiffness and endothelial function, and explores its potential mechanisms for the cardio protective effect. Material and Methods: In this study hypertensive subjects (N=57) of vitamin D deficient (< 20 ng /ml) and insufficient (20– 29 ng /ml) were supplemented to 60000 IU of vitamin D weekly for 6 weeks. Brachial artery flow mediated dilatation (FMD) was calculated before and after supplement. The sample had been processed by enzymatic immune assay method, and achial artery FMD had been measured by ultrasound (5–7MHz linear array transducer). Results: The obtained records of all the selected 57 patients were analyzed in pre and post supplement vitamin D. Before and after supplement the mean serum vitamin D level was 15.71±3.69 SD and 50.9±6.87SD. The mean achial artery FMD before and after supplement with vitamin D was 6.86±1.87 SD and 14.34±3.17SD respectively with p<0.001, which shows a significant association between serum level of vitamin D and FMD. Conclusion: This study support the hypothesis that serum vitamin D status is associated with vascular endothelial function among middle–aged/older adults, also demonstrate that lower level of serum vitamin D strongly associated with suppression of endothelial function.