Study of Association Between Vitamin �D–Receptor  Startcodon Polymorphism with Bmd Levels in Post  Menopausal Women of The South Indian District East  Godavari

GAYATRI CHELLURI; Dr. SRINIVASULU AMARA

Volume : III, Issue : IX, September - 2013

Study of Association Between Vitamin �D–Receptor Startcodon Polymorphism with Bmd Levels in Post Menopausal Women of The South Indian District East Godavari

Gayatri Chelluri, Dr. Srinivasulu Amara

Abstract :

Osteoporosis is one of the common chronic disorders found in post menopausal women, which is characterized by low bone mineral density (BMD). Vitamin –D Receptor (VDR) is a member of hormone receptor family. It modulates the action of genes which directly promotes intestinal calcium absorption. The aim of this study is to assess the BMD levels in post–menopausal women with respect to the FOK–I polymorphism of VDR gene.The present study includes one hundred and sixty post–menopausal women of East Godavari District of Andhra Pradesh, aged between 42 and 83. All subjects were tested for BMD using speed of sound (SOS) at calcaneum by QUS (qualitative ultrasound) method. Out of 160 subjects, 29 were normal, 63 were osteopenic and 68 were osteoporotic. PCR–RFLP analysis of start codon polymorphism (SCP) of VDR indicates that there is no significant association between VDR SCP polymorphism & Osteoporosis among South Indian East Godavari post–menopausal women