STUDY OF CYTOMORPHOLOGICAL SPECTRUM OF TUBERCULOUS LYMPHADENITIS AND CORRELATION WITH AFB POSITIVITY

Shaista  Choudhary; DR Krishna Kishore

Volume : VI, Issue : IV, April - 2016

STUDY OF CYTOMORPHOLOGICAL SPECTRUM OF TUBERCULOUS LYMPHADENITIS AND CORRELATION WITH AFB POSITIVITY

Shaista Choudhary, Dr Krishna Kishore

Abstract :

Background: Tubercular lymphadenitis is one of the most common causes of lymph node enlargement in developing countries. Fine needle aspiration cytology (FNAC) plays an important role in diagnosing Tubercular lymphadenitis and prevents unnecessary surgical intervention. Objectives: • To study cytomorphological appearances at FNAC suspected Tuberculous Lymphadenitis. • To detect the presence of acid fast organisms of these aspirates using Ziehl Neelsen stain. • To correlate the cytomorphological findings with Ziehl Neelsen staining Materials and Methods: A prospective study was conducted on 180 patients clinically suspected to have tubercular lymphadenitis were subjected to fine needle aspiration cytology study of lymphnode between june 2013 to july 2014. Cytomorphological patterns were categorized into three patterns. Pattern A– Epitheloid granuloma without necrosis , Pattern B– Epitheloid granuloma with necrosis, PatternC– Caseation necrosis granuloma. These observations were correalated Ziehl Neelsen stain. Results: 180 cases of peripheral lymphadenopathy involving cervical, axillary lymphnodes were subjected for FNAC, on clinical suspicion of tuberculosis.120 cases show cytological features of Tuberculous lymphadenitis. Pattern and number of cases as follows PatternA:24 cases, Pattern B:55 cases, PatternC:41 cases. Positive ZN staining was seen 58/120(48.3%) of cases. The cytological patterns of AFB positive cases Pattern A: 5/24(20.3%), Pattern B: 25/55(45.8%), Pattern C: 28/41(68.2%). Conclusion: Tuberculous Lymphadenitis is a common extra pulmonary manifestation of Mycobacterial tuberculosis infections. Fine needle aspiration cytology is a simple, cost effective, quick & safe out patient procedure and a reliable diagnostic tool for diagnosis of extra pulmonary tuberculosis when compared to surgical biopsy.