STUDY OF EFFECT OF DEXMEDETOMIDINE ON ENTROPY AS AN ADJUVANT TO HYPERBARIC BUPIVACAINE IN PATIENTS UNDERGOING ELECTIVE SURGERIES UNDER CENTRAL NEURAXIAL BLOCKADE

Geeta Kanithi; Srikanth Inturi; Shibani Padhy; R. Gopinath

Volume : VII, Issue : VII, July - 2017

STUDY OF EFFECT OF DEXMEDETOMIDINE ON ENTROPY AS AN ADJUVANT TO HYPERBARIC BUPIVACAINE IN PATIENTS UNDERGOING ELECTIVE SURGERIES UNDER CENTRAL NEURAXIAL BLOCKADE

Geeta Kanithi, Srikanth Inturi, Shibani Padhy, R. Gopinath

Abstract :

Background:

Sub arachnoid block, due to its inherent sedative effects, may potentially convert conscious sedation into hypnosis, with the unmonitored use of sedative drugs at standard doses,thereby increasing the probability of adverse events. Intrathecal α2–agonists like Dexmedetomidine, is now being used as a neuraxial adjuvant, provides stable hemodynamics with excellent intraoperative and postoperative analgesia with minimal side effects. The aim of our study to assess the effect of dexmedetomidine as an adjuvant to hyperbaric bupivacaine on entropy response in patients undergoing elective surgeries under central neuraxial blockade.

Material and methods: Hundred patients of ASA class I or II scheduled for lower abdominal or lower limb surgeries under central neuraxial blockade were studied. All patients were received intrathecal 15mg of 0.5% Bupivacaine (heavy) and 0.1µ/kg of Dexmedetomidine.

Results: Intrathecal dexmedetomidine as an adjuvant to hyperbaric bupivacaine in neuraxial blockade results in a decrease in response entropy (RE) and state entropy (SE) values.

Conclusion: The addition of dexmedetomidine to hyperbaric bupivacaine as an adjuvant provides clinically acceptable sedation levels without any significant hemodynamic changes.