Study of Effect of Remote Ischemic Post–Conditioning in ST Elevation Myocardial Infarct Patients

Dr. ROHINI PATEL; Dr. SWARNA GUPTA; Dr. MANOJ SINGH

Volume : VIII, Issue : VIII, August - 2018

Study of Effect of Remote Ischemic Post–Conditioning in ST Elevation Myocardial Infarct Patients

Dr. Rohini Patel, Dr. Swarna Gupta, Dr. Manoj Singh

Abstract :

Background:Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide.Patients with CHD suffer significant morbidity and mortality and Infarct size is a key determinant of prognosis. Aims and Objectives: To evaluate whether remote ischemic Post–conditioning (RIPC) could safely reduce enzymatic infarct size in patients with ST–elevation myocardial infarction (STEMI). To evaluated ECG changes & Echocardiographic in patients who underwent RIPC. Materials and methods: This institutional study consists of total 52 subjects (n=26 in the case group and n=26 in control group), aged between 18–50 year, with ST–elevation myocardial infarction (STEMI).. Results: Our study findings show that the maximum no. of patients were present in 41–51 years of age group (n=37, 71.15%), Most of the subjects were male (n=45, 86%). The frequencyof Smoking & Tobacco was the highest (26.92 % & 19.23 % respectively).Significantdifference present between Trop T (Quantitative) levels in RIPC (case) group and control group at various time intervals with a sequential decline in trop T levels with time (P<0.0001*). RIPC (cases) group having significantly lower TROP T at all three–time interval (P<0.0001*) as compared to control group. There was a significant difference was present between ST resolutions in RIPC (case) group at various time intervals. A significant difference in ST resolution was observed between study groups at day 1 (P=0.013*) and highly significant at day 3 (P=0.004*).Maximum area under the ROC curve was shown at day 3 with a significance of P<0.0001*. Conclusion:RIPC definitely reduces infarct size and has a great impact on ST Segment resolution in ECG. RIPC helps early recovery & better reperfusion as compared to control. However, this is a small study which needs further evaluation in a large study.