Study of Histopathological Diagnosis, Clinicoradiological Findings and Importance of Immunohistochemistry in Surface Epithelial Ovarian Tumors: A Study of 100 Cases

Dr. Dhaval Jetly; Dr. Siddharth Thummar; Dr. Neha Nagrani

Volume : IX, Issue : II, February - 2019

Study of Histopathological Diagnosis, Clinicoradiological Findings and Importance of Immunohistochemistry in Surface Epithelial Ovarian Tumors: A Study of 100 Cases

Dr. Dhaval Jetly, Dr. Siddharth Thummar, Dr. Neha Nagrani

Abstract :

Ovarian Cancer is one of the leading cancers in Indian women. In India, ovarian cancer is the third leading site of cancer among women, trailing behind cervix and east cancer. A detailed clinical history, abdomen and pelvic examinations, determination of CA–125 levels and ultrasonography are necessary steps in making diagnosis. Use of immunohistochemistry (IHC) has significant role in diagnostic ovarian pathology in recent years. In the Surface Epithelial Tumors the most common problem is its discernment from metastasis. The use of differential cytokeratins, primarily CK7 and CK20, as well as Cdx–2, beta–catenin, and P504S is helpful in differentiating between metastatic adenocarcinoma, particularly of colorectal origin. The present study aimed to compare the Clinicoradiological findings and its correlation with Histopathological diagnosis in Surface Epithelial Ovarian Tumors & utility of Immunohistochemistry in diagnosis of Surface Epithelial Ovarian Tumors. A total of 100 cases histopathologically diagnosed as surface epithelial ovarian tumors on paraffin section were included in the present study and it concluded that Pre–operative Serum CA 125 levels and Radiological Findings have Limited Role in Categorizing Ovarian Tumors. Thorough Sampling & Careful Histopathological Examination is Most Helpful in typing & subtyping of Tumor. Immunohistochemistry plays an important role in Differentiating Primary Ovarian Epithelial Tumors from Metastatic Tumors and in Histologic Subtyping of the Tumors in Poorly Differentiated Cases. It should be interpreted in view of Clinical History, Radiological Findings and Histomorphological Findings