STUDY OF HYPOTHYROIDISM IN CHRONIC KIDNEY DISEASE PATIENTS

Dr .CHADA RAMESH; Dr. M. PAVAN  KUMAR; Dr. GANGHADHAR   BATTHINI

Volume : VI, Issue : VI, June - 2016

STUDY OF HYPOTHYROIDISM IN CHRONIC KIDNEY DISEASE PATIENTS

Dr . Chada Ramesh, Dr. M. Pavan Kumar, Dr. Ganghadhar Batthini

Abstract :

 BACKGROUND: The importance of understanding the impact of thyroid dysfunction on renal function is highlighted by recent studies indicating subclinical and clinical hypothyroidism is common in patients with estimated GFR , <60 ml/min per 1.73 m2, petitioning the question of whether hypothyroidism might be contributing to the low GFR in some of these individuals. AIM: The aim is to study the prevalance and trend of hypothyroidism as the renal impairement increases in CKD patients. OBJECTIVE: 1.To estimate the glomerular filtration rate in chronic kidney disease patients and correlate with their thyroid levels STUDY DESIGN: prospective observational study MATERIAL AND METHODS: This study included 50 patients of chronic kidney disease from stage I to stage V and their thyroid profile was done to know the prevalence of clinical and subclinical hypothyroidism in the study population. Statistical methods: Statistical analysis was performed using the GraphPad InStat software version 3.10 for Windows. Data are expressed as mean+/– SD. The Fisher’s exact test was used for comparison of categorical variables. Student’s unpaired t–test was used to compare continuous variables. . P–value< 0.05 is considered as significant. RESULTS: 1. Prevalence of hypothyroidism in chronic kidney disease patients is about 19%. 2. Prevalence of hypothyroidism increases as the severity of the renal impairment increases. Its prevalence in CKD Stage IV, V patients is 18%, 31% respectively. CONCLUSION: This study showed that Total T3 and Total T4 levels were lower than normal specially among patients with stage 4 & 5 CKD and a progressive reduction in values of Total T3 and Total T4 were noticed as the severity of renal failure increased .