Volume : V, Issue : X, October - 2015

Study of IgM anticardiolipin antibodies in pregnant ladies

Goel Neha, Tuli Anita

Abstract :

 Background : Abortion is termination of pregnancy by any means before the fetus is sufficiently developed to survive on its own. The growing recognition that in this group of patients there may be an immunologic basis aroused interest in research workers.The anticardiolipin antibodies (aCL) which are commonly associated with recurrent pregnancy loss are lgG and lgM. lgM antibody is the largest immunoglobulin and first to appear in an immune response. Women with phospholipid antibodies have a fetal loss of 90% when no specific treatment is given during pregnancy so this study was planned to find Anticardiolipin antibody levels (IgM) in patients of Abortions.Material/Methods: A total of 125 pregnant subjects were included in the study which includes study group (75 subjects) and a control group (50 subjects). Their blood was tested to assess the level of IgM aCL by enzyme–linked immunosorbent assay (ELISA). In the study group a total of 18 (24%) subjects were positive for raised IgM anticardiolipin antibodies. In the control group 2 (4%) subjects were positive for IgM anticardiolipin antibody all of whom had levels in the insignificantly positive range. Mean levels of anticardiolipin antibody IgM in control group was 2.57 ± 1.44 MPL units. p <0.001, highly significant. Result :Patients with increased IgM levels indicate a higher antibody burden with greater antigenic affinities explaining IgM mediated pregnancy wastage

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Goel Neha, Tuli Anita Study of IgM anticardiolipin antibodies in pregnant ladies Indian Journal of Applied Research, Vol.5, Issue : 10 October 2015

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