Volume : IX, Issue : III, March - 2019

STUDY OF INCIDENCE OF BLEEDING IN PATIENTS OF AMI AFTER THROMBOLYTIC THERAPY

Dr. Prabhakar S. Jirvankar, Dr. Hemant Nanda Chimote

Abstract :

Due to a large increase in the number of patients with thrombotic diseases like atrial fiillation, prosthetic heart valves, cardio embolic stroke, AMI, Pulmonary embolism and venous thrombosis worldwide, in recent years antithrombotic therapy is often chosen to treat such high risk patients1.In AMI most patient need either PCI or IV thrombolysis to achive reperfusion. Though the antithrombotic therapy has improved the outcome, the risk of bleeding remains the significant issue.1 The risk of bleeding has been evaluated in many clinical trials using various schemas like CHADS2 score, CHA2DS2–VAS score, HEMORR2HAGES score. The new bleeding risk score HASBLED( HTN, Abnormal renal / liver function, stroke history, bleeding history, Labile International normalized Ratio, Elderly, Drug/Alcohol, 1 point for each risk factor, max 9) has recently proposed as a practical tool to assess the individual bleeding risk2, Patients with different risk factors receiving thrombolytic therapy are prone to bleeding, which has been proved in many clinical studies. The aim of this study was to monitor the incidence of bleeding in patients undergoing thrombolytic treatment for acute of myocardial infarction. We studied 100 patients of AMI for incidence of bleeding after thrombolysis in ICCU of Government Medical College Aurangabad from December 2013 to November 2015. 13% patients developed bleeding as a complication of thrombolysis . 53 % patients had deranged INR & 23% patients required blood blood transfusion. According to HASBLED scoring system, 67% patients were in low risk group,27% patients were in intermediate risk group and 6 % were in high risk group. Though thrombolysis safe and highly effective treatment in AMI Patients are more likely to have risk of bleeding complications. Therefore patients should be evaluated for risk factors for bleeding such as advanced age, Male sex, DM,HTN, Alcohol consumption, prior to starting thrombolytic therapy. We did not found statistically significant association between HASBLED score and incidence of bleeding probably due to smaller sample size

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

STUDY OF INCIDENCE OF BLEEDING IN PATIENTS OF AMI AFTER THROMBOLYTIC THERAPY, Dr. PRABHAKAR S. JIRVANKAR, Dr. HEMANT NANDA CHIMOTE INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-3 | March-2019

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