Volume : VII, Issue : IX, September - 2017

STUDY OF INTRAVENOUSLY ADMINISTERED DEXMEDETOMIDINE ON ISOFLURANE REQUIREMENT AND PERIOPERATIVE HAEMODYNAMIC STABILITY IN ELECTIVE SURGERY

Dr. Pauravi Bhatt, Dr. Priyen Patel, Dr. Devanshi Shah, Dr. Nupur Doshi

Abstract :

 BACKGROUND :Dexmedetomidine is an α–2 adrenoreceptor agonist, The purpose of this study was to evaluate the effect of intravenous dose of dexmedetomidine on cardiovascular response resulting from laryngoscopy and endotracheal intubation, need for anaesthetic agent and perioperative haemodynamic stability METHOD: Sixty patients scheduled for elective surgery were randomised into two groups (dexmedetomidine group and placebo group, n = 30 in each group). Fentanyl 1 μ/kg was administered to all patients as premedication. Anaesthesia induction was done with Thiopentone sodium and succinycholine and anaesthesia was maintained  with 33% oxygen :66% nitrous oxide, Vecuronium and  Isoflurane. Isoflurane concentration was adjusted to maintain systolic blood pressure and/or heart rate within 20% of preoperative values. Haemodynamic parameters were recorded after intubation, 5minutes,10minutes ,30minutes,60minutes,90minutes and 120 minutes, after infusion stopped, after reversal and extubation. After extubation, All the patients in both the groups were monitored for VAS and sedation for at least 4 hours after surgery. Post–operative pain intensity was assessed using VAS score RESULTS: after intubation and laryngoscopy there was an increase in pulse and blood pressure in both the group from baseline values. Maximum increase in pulse rate and blood pressure occur at intubation in both groups. But this increase statically significant in saline group patients Mean Isoflurane concentration over intraoperative period is significantly less in Dexmetodomidine group as compared to saline group.Fentanyl requirement during the operation was reduced in the dexmedetomidine group . During postoperative period Ramsay sedation score is more in Dexmetodomidine group patients in comparison to saline group, but this difference is not statically significant. CONCLUSION:  Dexmedetomidine, as an adjuvant in general anaesthesia for elective surgeries provided a stable haemodynamic profile in perioperative period and effectively blunted pressor response to intubation and extubation, leading to minimal requirements for additional analgesics and potent inhalational agents. There was also an acceptable recovery profile. 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Pauravi Bhatt, Dr. Priyen Patel, Dr. Devanshi Shah, Dr. Nupur Doshi, STUDY OF INTRAVENOUSLY ADMINISTERED DEXMEDETOMIDINE ON ISOFLURANE REQUIREMENT AND PERIOPERATIVE HAEMODYNAMIC STABILITY IN ELECTIVE SURGERY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-9 | September-2017

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