STUDY OF METABOLIC SYNDROME IN CORRELATION WITH HYPERURICEMIA

Dr.A R KRISHNAMOHAN; Dr.KIRAN KUMAR P

Volume : VI, Issue : I, January - 2016

STUDY OF METABOLIC SYNDROME IN CORRELATION WITH HYPERURICEMIA

Dr. A R Krishnamohan, Dr. Kiran Kumar P

Abstract :

BACKGROUND: Insulin decreases uric acid excretion. So there must be some link between hyperuricemia and insulin resistance. But the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear. Our objective was to determine the prevalence of the metabolic syndrome according to serum uric acid levels in a medical college hospital. METHODS: By using data from 850 participants who aged 20 years and more who attended OPD during the period of January 2014 to May 2015, the prevalence of the metabolic syndrome at different serum uric acid levels was determined. Metabolic syndrome was defined as per National Cholesterol Education Programme Adult Treatment Panel (NCEP/ATP) III criteria. RESULTS: The prevalences of the metabolic syndrome according to the NCEP/ATP III criteria were 16% for uric acid levels less than 6 mg/dL, 25% for uric acid levels from 6 to 6.9 mg/dL, 42% for uric acid levels from 7 to 7.9 mg/dL, 52% for uric acid levels from 8 to 8.9 mg/dL, 60% for uric acid levels from 9 to 9.9 mg/dL, and 66% for uric acid levels of 10 mg/dL or greater. The prevalence of individual metabolic abnormalities of the metabolic syndrome were also calculated CONCLUSIONS: With increasing levels of serum uric acid the prevalence of the metabolic syndrome increased substantially. Hence metabolic syndrome must be considered as a frequent comorbidity of hyperuricemia and should be treated to prevent serious complications.