Study of Muller Cells of Retina in Mice and Human Subjects suffering from Night Blindness using Electroretinography

Homami; E; Shushtarian; S.M.

Volume : IV, Issue : XII, December - 2014

Study of Muller Cells of Retina in Mice and Human Subjects suffering from Night Blindness using Electroretinography

Homami, E, Shushtarian, S. M.

Abstract :

Aim: Night blindness or nyctalopia is diseases of visual system which is accompanied by night vision problem. It is reported that different retinal layers of these patients are deteriorated. The aim of present work is to look for the status of Muller cells of retina in human & mice population suffering from night blindness. Method: Forty mice were taken for the purpose of present work, 20 mice with normal retina as control and 20 mice with night blindness as case groups. Same number of human subjects were taken into consideration i.e. 20 human subjects with normal retina & 20 night blind patients. Electroretinography (ERG), was recorded in total animal and human subjects. Amplitude (µv) & latency (msec) was measured in total population i.e. animal and human subjects. Mean & standard deviation was calculated in control groups & according to the results, number of abnormal ERG, b wave in case groups were estimated. Results: Seventeen mice and thirteen human in case groups had abnormal ERG b waves. Conclusion: It is a well known fact that ERG b wave originates from Muller & bipolar cells in retina, therefore the abnormal ERG b wave in case groups is an indication of malfunctioning of Muller cells in night blind mice & human subjects which will be discussed in ief in full paper.