STUDY OF PRESSOR RESPONSE COMPARING TWO DIFFERENT DOSES OF DEXMEDETOMIDINE

P.Ramesh; Farooq Basha S

Volume : VI, Issue : X, October - 2016

STUDY OF PRESSOR RESPONSE COMPARING TWO DIFFERENT DOSES OF DEXMEDETOMIDINE

P. Ramesh, Farooq Basha S

Abstract :

A randomized prospective double blind study entitled “STUDY OF PRESSOR RESPONSE COMPARING TWO DIFFERENT DOSES OF DEXMEDETOMIDINE” was carried out at ACSR GMC, Nellore, in the Department of Anaesthesiology during the period from August 2015 to July 2016. This study was done to compare the effectiveness of two different doses of Dexmedetomidine in attenuating pressor response to laryngoscopy and endotracheal intubation. Dexmedetomidine, an alpha–2 adrenoreceptor agonist was introduced into clinical practice as a short term sedative (<24hrs) and has been targeted for use in the perioperative period. Dexmedetomidine decreases sympathetic tone with attenuation of neuroendocrine and hemodynamic responses to anaesthesia and surgery, reduces anaesthetic requirement, causes sedation and analgesia. Present study concludes that premedication with Inj. Dexmedetomidine in the dose of 1µg/kg body weight as I.V infusion significantly attenuates the pressor response to laryngoscopy and endotracheal intubation when compared to inj.Dexmedetomidine in the dose of 0.5µg/kg body weight I.V infusion without significant side effects.