STUDY OF PREVALENCE AND PATTERNS OF SOME HEMOGLOBINOPATHIES IN CHANDRAPUR DISTRICT

SHRIKANT W MASRAM; BHUSHAN NAITAM; M V BIMANPALLI; SARIKA KOKANE

Volume : VII, Issue : VIII, August - 2017

STUDY OF PREVALENCE AND PATTERNS OF SOME HEMOGLOBINOPATHIES IN CHANDRAPUR DISTRICT

Shrikant W Masram, Bhushan Naitam, M V Bimanpalli, Sarika Kokane

Abstract :

Background: Hemoglobinopathies are considerable health problem in central india particularly in Chandrapur district due to lack of awareness and insufficient screening programs. Data regarding prevalence of different patterns of abnormal hemoglobins in different age groups and sex of positive cases in this region is scarce. Aim: In view of facts described above, it was decided to determine prevalence of different patterns of abnormal hemoglobins in different age groups and sex of positive cases in Chandrapur district. Methodology: The study is laboratory record based and having about 510 screened individuals coming to the OPD and IPD of Government Medical College and Hospital Chandrapur in last few months of the year 2016. All the samples were tested for sickle solubility test and then subjected to hemoglobin electrophoresis for pattern confirmation followed by HPLC. Result: prevalence of hemoglobinopathies was 41%. Our study shows female preponderance (54%) over male (46%) regarding abnormal hemoglobins. The most of the positive cases of our study were found in adult age group (>19yrs). Prevalence percentage of AS and SS pattern of hemoglobin was 33%. AS pattern of abnormal hemoglobin was the commonest pattern in pediatric age group. It was followed by HPFH and SS hemoglobinopathy While prevalence of both AS and SS pattern were high (34%) seen in adolescent age group. Prevalence of SβT, βT trait, βT and SF were 12%, 6%, 3%, 9% respectively. Conclusion: This study provides data about the prevalence of different patterns of hemoglobinopathies in different age group which is scarce as far as Chandrapur district is concerned. Most of the cases are detected in adult age group proves that there is lack of awareness about hemoglobinopathies in this region. More screening programs, sufficient and effective diagnostic and therapeutic facilities are required for early detection of cases and lower the morbidity and mortality due to hemoglobinopathy particularly in central India.