Volume : VII, Issue : VIII, August - 2017

STUDY OF PROSTATIC LESIONS IN CORRELATION WITH PSA LEVELS.

Dr P. V. Kiran Kumar

Abstract :

 Background: Prostate specific antigen (PSA) is a protein produced by the cells of the prostate gland. It is generally increased in diseases such as prostatitis, hyperplasia, and malignancy, but the correlation between various lesions affecting the prostate gland and their corresponding rise in PSA value is not constant  and exceptions may occur.

Aims and Objective: The aim of this study was to find out the spectrum and distribution of various prostatic lesions affecting men, with respect to their age and to find out the correlation between serum total PSA levels and histological findings. Materials and Methods: This study included  150 samples of transurethral resection of the prostate (TURP) received in the histopathology laboratory, over a period of 2 year. All representative tissue sections were taken and paraffin embedded blocks were made, which were finally sliced in a standard microtome of 3microns thickness  and stained with hematoxylin and eosin stain. They were examined under light microscopy for final evaluation and diagnosis. PSA levels were recorded in all the patients before surgical procedure was undertaken. Results: About 51% of subjects studied were in the age group of 61–70 years. Maximum number of subjects had PSA ranging from 0 to 4 ng/ml (48.66%). Benign prostatic hyperplasia (38.75%) with or without prostatitis  was the predominant lesion(46%). Conclusion: We were able to determine the spectrum of prostatic lesions in different age group and the results indicate that the chances of finding malignancy with increasing values of PSA are more, but not as a rule. It can only give a clue to the histopathologist to examine the sections more thoroughly.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr P.V. Kiran Kumar, STUDY OF PROSTATIC LESIONS IN CORRELATION WITH PSA LEVELS., INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾8 | August‾2017

Number of Downloads : 224

References :