STUDY OF RELATIONSHIP BETWEEN C–REACTIVE PROTEIN AND ESSENTIAL HYPERTENSION IN URBAN POPULATION OF MALWA REGION

Deepak Parmar; Himanshu Dagor

Volume : IX, Issue : VIII, August - 2019

STUDY OF RELATIONSHIP BETWEEN C–REACTIVE PROTEIN AND ESSENTIAL HYPERTENSION IN URBAN POPULATION OF MALWA REGION

Deepak Parmar, Himanshu Dagor

Abstract :

Background: Rising evidence associates inflammation to atherosclerosis. Even though a few study have recommended the role of inflammatory process in patients with essential hypertension and coronary artery disease cases. Elevated levels of C–reactive protein (CRP), an easily measured inflammatory marker, have been prospectively linked with a high risk of hypertension. However, the association of markers, other than CRP, with the possibility of developing hypertension remains mostly unproven. The activation of the renin–angiotensin system (RAS) is implicated in the pathogenesis of hypertension and the development of coronary artery disease. In addition to its effect on hypertension, angiotensin II also acts as a proinflammatory mediator. Antagonism of the RAS may enhance cardiovascular morbidity other then BP control, by decreasing vascular inflammation and remodeling. Its overall role in essential hypertension and coronary artery disease far from being understood. Present study is intended to examine whether CRP and systemic inflammation, are linked with essential hypertension or not. Methods: One hundred cases of essential hypertension attending Medicine OPD in Aurobindo Medical College and Hospital, Indore were included in the study and their CRP levels and other regular investigations were done by appropriate standard methods. Results: We found that about 48 % cases of essential hypertension were having elevated CRP levels. Conclusions: CRP levels are strongly related with development of essential hypertension, which imply that essential hypertension due to atherosclerosis is a part of inflammatory process which we concluded in present study.