Study of Serological Profile of Torch Infections in Women with Bad Obstetric History

Dr. Anju Agrawal; Dr. S. K. Singh; Dr. R. K. Maheshwari; Dr. J. K. Goyal

Volume : VI, Issue : V, May - 2016

Study of Serological Profile of Torch Infections in Women with Bad Obstetric History

Dr. Anju Agrawal, Dr. S. K. Singh, Dr. R. K. Maheshwari, Dr. J. K. Goyal

Abstract :

Introduction: The primary infections with TORCH agents, remain a major problem in the women with Bad Obstetric History (BOH). Prenatal screening for antibodies to TORCH infectious agents by serology is an important tool for diagnosis. Aims and objectives: To determine the occurrence of IgM and IgG antibodies status against TORCH infections in sera of women with BOH in a tertiary care hospital of North India. Material and method(s): In this prospective observational study, 130 women with BOH were included. Serology by detecting IgM and IgG antibodies specific to TORCHagent was carried out either by ELISA or Chemiluminesense method. Result: The overall IgM antibodies seropositivity of TORCH were 99(76.15%). The IgM/IgG sero positivity to Toxoplasma, Rubella, CMV and HSV were 21.54/27.69%, 35.38/60.00%, 19.23/78.46%, and 18.46/23.85% respectively. Maximum number of IgM seropositives cases of abortion 39(39%) and congenital malformations 08(28.57%) were associated with Rubella, still birth 04(23.52%) and preterm 03(16.67%) were associated with Toxoplasma and Rubella. Conclusion(s): A previous history of pregnancy wastage and the serological reaction for TORCH infections during current pregnancy must be considered while managing BOH cases so as to reduce the adverse fetal outcome.