STUDY OF THE ACTIVITY OF SERUM PARAOXONASE AS A MARKER OF SEVERITY OF ATHEROSCLEROSIS IN POST MENOPAUSAL WOMEN AND ITS CORRELATION WITH LIPID PROFILE IN THESE WOMEN.

Dr Chaganti Sridevi; Dr. Sowjanya U.V.P.U

Volume : VII, Issue : XII, December - 2017

STUDY OF THE ACTIVITY OF SERUM PARAOXONASE AS A MARKER OF SEVERITY OF ATHEROSCLEROSIS IN POST MENOPAUSAL WOMEN AND ITS CORRELATION WITH LIPID PROFILE IN THESE WOMEN.

Dr Chaganti Sridevi, Dr. Sowjanya U. V. P. U

Abstract :

Coronary artery disease is one of the important causes of death among older women according to Global Burden of Disease 2010 Estimates. Altered lipid profile is a major risk factor of this disease. Paraoxonase is a serum esterase associated with HDL–C and contributes to protect against LDL–C oxidation. Post–menopausal women are known to have altered lipid profile so present study is designed to estimate serum Paraoxonase activity and correlate with lipid profile in post–menopausal women.

The study was conducted on 50 post–menopausal women with no history of conditions altering lipid profile and 50 healthy pre–menopausal controls. Serum Paraoxonase activity was estimated by spectrophotometric method and lipid profile by enzymatic assay methods.

Serum Paraoxonase activity and HDL–C levels were low and TC, and LDL–C levels were high in post–menopausal women compared to healthy pre–menopausal controls (p<0.01). Serum Paraoxonase levels were decreased in post–menopausal women compared to pre–menopausal women (p<0.01). Serum Paraoxonase activity correlated positively with HDL–C.

Decrease in HDL associated Paraoxonase activity with dyslipidaemias in post–menopausal women may accelerate LDL oxidation leading to atherogenesis.

Hence post–menopausal women with dyslipidaemia along with decreased serum Paraoxonase levels could be more prone and susceptible to accelerated atherogenesis leading to coronary artery disease.